The SM-EGFR-DB is a comprehensive compendium of all somatic mutations in EGFR that have been identified in human cancers and reported in peer-reviewed literature
The database is split into:
NSCLC |
Other Cancers |
|
|---|---|---|
| EGFR somatic mutations in non-small cell lung cancer (NSCLC) |
EGFR somatic mutations in all other cancer types |
In addition the database supports:
- information concerning the cumulative frequency (incidence) of somatic mutations according to the major clinicopathological factors of gender (sex), smoking history (smoking status), histology (adenocarcinoma versus other) and ethnicity (Asians versus Caucasians)
- supplementary information on treatment characteristics and response criteria
- cumulative data on mutational spectrum and response characteristics for TKI treated patients per mutation
- supplementary information on sample source and methods of analysis
The main objectives of this free-access information resource are to provide comprehensive updated (q6m) analytical data regarding the frequency and spectrum of SM-EGFR in TKI naïve populations and also in TKI treated populations facilitating access to clinicopathological related factors and mutation specific response rates for TKI treatment related purposes.
The database provides information aimed at a broad range of scientists and clinicians who work in a variety of research areas:
- Basic scientists; in understanding the etiology of mutations, structural and functional purposes
- Molecular Pathologists; to interpret diagnostic results and convey their potential clinical significance to the patients and the treating physician
- Clinicians/Medical Oncologists; to gain access to more clearly offer relevant advice to their patients in order to offer rational, informative and objective opinions on their treatment decisions.
